Molecular Modeling Studies on Biochanin-A as a Potential Dual inhibitor for VEGFR-2 and Cyclin D1-CDK-4 Complex

Ab-Initio and Conformational Analysis of a Potent VEGFR-2 Inhibitor: A Case Study on Motesanib

Vascular endothelial growth factor receptor-2 (VEGFR-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. It has been revealed that VEGFR-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. In this regard, targeting the VEGFR-2 has been considered as an ...

Ab-Initio and Conformational Analysis of a Potent VEGFR-2 Inhibitor: A Case Study on Motesanib

Vascular endothelial growth factor receptor-2 (VEGFR-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. It has been revealed that VEGFR-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. In this regard, targeting the VEGFR-2 has been considered as an ...

Cyclin E1-CDK 2, a potential anticancer target

CCNE1 is one of the most frequent gene amplifications in high grade serous ovarian cancers (HGSOCs), which occurs in at least 20% of HGSOC and in 30% of established ovarian cancer cell lines. Studies with both primary and metastatic ovary tumor specimens further suggest that the abundance of CCNE1 protein expression correlates with tumor progression and predicts a poor prognosis in ovarian canc...

Binding of HTm 4 to KAP / CDK 2 / Cyclin A complex enhances the phosphatase activity of KAP , dissociates Cyclin A , and facilitates KAP dephosphorylation of CDK 2

1 Department of Nutrition, Kyushu Women’s University, Jiyugaoka 1-1, Kitakyushushi 807-8586, Japan; 2 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; 3 Queen’s Center for Biomedical Research, Queen’s Medical Center, Honolulu, HI 96813, USA; 4 Department of Health Promotion & Human Behavior, Kyoto University Graduate School of Public H...

CDKN 2 B ( cyclin - dependent kinase inhibitor 2 B ( p 15 , inhibits CDK 4 ) )